MK-677 is an orally-available, non-steroidal “hormone mimetic” that has delivered notable outcomes in animal studies, and it is currently the subject of ongoing research in both Europe and North America.
MK-677 mimics the activity of ghrelin, which is a hormone naturally produced in the stomach, small intestine and brain that increases appetite and exerts growth-hormone secreting effects. As aging is associated with decreases in growth hormone levels and circulating concentrations of insulin-like growth factor I (IGF-I), one exciting approach to the prevention of age-related decreases in skeletal muscle mass and strength involves the use of a ghrelin “mimetic” such as MK-677.
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